About   About
Prof. Alik Honigman (Ph.D)

Prof. Alik Honigman (Ph.D)

Head of Biotechnology Department


1967, B.Sc., The Hebrew University of Jerusalem, Israel. Faculty of Science. Main Subject: Microbiology and Genetics.
1969, M.Sc., The Hebrew University-Hadassah Medical School, Jerusalem, Israel. Dept. Chemical Microbiology.
Thesis: ”Genetic control of the life cycle of Bacteriophage P1”
1970-1975, Ph.D. student, The Hebrew University-Hadassah Medical School, Jerusalem, Israel. Thesis: "Genetics and Biochemical Studies of the early Regulation of Bacteriophage lambda".
1975-1977 Research Associate, McArdle Laboratory for Cancer Research, University Of Wisconsin, Madison, WI. USA.

Positions held

2012-2016 Head of school of medical and life sciences, Hadassah Academic College.
2012-now Head of Biotechnology program, Hadassah Academic College
2012-now Chair of academic appointment committee Hadassah Academic College
2006-2010 Chairman of Planning and Development committee of the Faculty of medicine of the Hebrew University, Jerusalem
2004-now The Lady Davis Chair in Experimental Medicine and Cancer Research.
2006-2010 Chairman of the committee for recruitment of new academic faculty members.
2005 Full professor in molecular genetics.
2000-2009 Chairman of the Interdepartmental Equipment Unit of the Faculty of Medicine, the Hebrew University, Jerusalem, Israel.
1996-now Chairman of the scientific advisory board of Promega Biotechnology Corporation.
1994-1995 Promega Corp. and the University of Wisconsin, Visiting Professor of Molecular Virology
1992-1997 Institute of Microbiology - Head of Curriculum Committee
1990-1995 Head of Department of Molecular Genetics, The Hebrew University-Hadassah Medical School, Jerusalem.
1984-1985 Visiting Scientist , NIH, NCI-FCRF, Fredrick, Maryland,.


Broza, M., Sneh B., Yawetz A., Oron U., and A. Honigman A., (1984).Commercial application of Bacillus thuringiensis var. entomocidus to cotton fields for the control of Spodoptera littoralis Boisduval (Lepidoptera,Noctuidae). J. Econ. Entom. 77:1530-1533.

Oron, U., Skolover M., Yawetz A., Broza M., B. Sneh and Honigman A., (1985). Ultrastructural changes in larval midgut epithelium of Spodoptera littoralis following ingestion of endotoxin of Bacillus thuringiensis var.entomocidus. J. Invertebr. Pathol. 45:353-355.
25. Honigman, A., Bar-Shira A., Silberberg H. and Panet A.,(1985). Generation of a uniform 3' and RNA of murine leukemia virus. J. Virol.53:330-334.

Honigman, A., J. Mahajna, S. Altuvia, S. Koby, D. Teff, H.Locker-Giladi, H. Hyman, C. Kronman and A. Oppenheim (1985). Plasmid vectors designed for the analysis of transcription termination signals. Gene. 36:131-141.

Oppenheim, A.B., J. Mahajna, S. Altuvia, S. Koby, D. Teff, H.Locker-Giladi, H. Hyman, C. Kronman and A. Honigman (1985). Utilization of control elements for gene expression studies in E. coli, in: Recombinant DNA Research and Viruses, Y. Becker, Editor. Martinus Nijhoff Publishing,Boston, pp. 73-86.

Honigman, A., H. Hyman and A.B. Oppenheim (1985). Analysis of viral transcription-termination signals, in: Viral Messenger RNA, Y. Becker,Editor. Martinus Nijhoff Publishing, Boston, pp. 61-75.

Honigman, A. and G. Nedjar-Pazerini (1986). Cloning and expression of the Lepidoptecan toxin produced by B. thuringiensis in E. coli. Gene. 42:69-77.
30. Hyman, H. and A. Honigman (1986). Transcription termination and processing sites in the lambda PL operon. J. Mol. Biol. 189:131-141.

Mador, N., A. Panet and A. Honigman (1989). Translation of gag pro and pol gene products of human T-cell leukemia virus type 2. J. Virology 63:2400-2404.

Unge, T., H. Ahola, K. Bhikhabhai, S. Lovgren, E. Fenyo, A. Honigman,A. Panet, J. Gronowirz and B. Strandberg (1990). Expression, purification and crystallization of the HIV-1 reverse transcriptase (RT). Aids Research and Human Retroviruses 6:1297-1303.

Honigman, A., Wolf D, Yaish S, Falk H. and Panet A., (1991). cis-acting RNA sequences control the gag-pol translation readthrough in murine leukemia virus. Virol. 183:313-319.

Israel, S. and Honigman A., (1991). A bioluminescence assay for gene expression by continuous growing mammalian cells: application in detection of human immunodeficiency virus type I. Gene, 104:139-145.

Bar-Shira, A., Panet A., and Honigman A., (1991). An RNA secondary structure juxtaposes two remote genetic signals for HTLV-I RNA 3' end processing. J. Virol. 65:5165-5173.

Falk, H., Mador N.,. Udi R., Panet A. and Honigman A., (1993). Two cis-acting signals control ribosomal frameshift between human T-cell leukemia virus type II gag and pro genes. J. Virol. 67: 6273-6277.

Bentwich Z., Lawatti, A., Vonsover S., Honigman A, Israel S., (1993) Tat detection assay by Luminescence. J. ACQ Immun. Def. Synd and Human Retroviruses. 6:728.
38. Kollmus, H., Honigman A., Panet A.and Hauser H., (1994). Sequence and distance of slippery site and stem-loop define the strength of ribosomal frameshifting in HIV-1 and HTLV-2 in vivo. J. Virol. 68:6087-6091.

Honigman, A., Falk H., Mador N., Rosental T. and Panet A., (1995). Translation efficiency of the human T-cell leukemia virus (HTLV) gag gene modulates the frequency of ribosomal frameshifting. Virology 208:312-318.

Israel, S., Mendelovitz M.and A. Honigman A., (1995). Transactivation of human T-cell leukemia virus type 1 by Herpes simplex virus type 1. Virus Genes 9:269-276.

Nir-Paz, R., Israel S., Honigman A. and Kahane I., (1995). Mycoplasmas regulate HIV-LTR-dependent gene expression. FEMS-Microbiol. Letters 128:63-68.

Wolf, D.G., Honigman, A., Lazarovits, J., Tavor, E. and A. Panet A., (1998). Characterization of the human cytomegalovirus UL97 gene product as a virion-associated protein kinase. Archives of Virology. 143:1223-1232.

Wolf, D.G., Yaniv, I., Honigman, A., Kassis, I., Schonfeld, T., and Ashkenazi S. (1998). Early emergence of ganciclovir-resistant human cytomegalovirus strains in children with primary combined immunodeficiency. J. Infect. Dis.178: 535-538.

Axelrode J., Honigman, A., (1999) A sensitive and versatile bioluminescence bioassay for HIV-1 infection carried on Adenoviral vectors. AIDS research and human retroviruses.15: 759-767.

Goren, I., Tavor, E., and Honigman, A., (1999) Gene regulation mediated by interaction between HTLV-1 promoter elements and transcription factors TAX and CREB. Virology, 258:303-312

Segev, H, Honigman, A. Rosen, H. and Leitersdorf, A. (2000) Transcription regulation of sterol 27-hydroxylase gene and promoter mapping. Atheriosclerosis, 156: 339-347.

Wolf DG, Yaniv I, Ashkenazi S, Honigman A.(2001) Emergence of multiple human cytomegalovirus ganciclovir-resistant mutants with deletions and substitutions within the UL97 gene in a patient with severe combined immunodeficiency. Antimicrobial Agents and Chemotherapy ; 45:593-595.

Honigman A, Zeira E, Ohana P, Abramovitz R, Tavor E, Bar I, Zilberman Y, Rabinovsky R, Gazit D, Joseph A, Panet A, Shai E, Palmon A, Laster M, Galun E. .( 2001 ) Transgene Expression in Live Animals. Mol Ther ;4:239-249.

Goren I., Tavor E., Goldblum A. and Honigman A, (2001) Two Cysteine Residues in the DNA-Binding Domain of CREB Control Binding to CRE and CREB Mediated Gene Expression , J. Mol. Biol., 313: 695-709.

Shai E., Falk H., Honigman A., Panet A. and Palmon A.,(2002) Gene transfer mediated by different viral vectors following direct cannulation to mouse submandibular salivary glands. European Journal of Oral Sciences, 110:254-260.

Bar I , Zilberman Y., Zeira E., Galun E., Honigman A., Turgeman G., Clemens T. , Gazit Z., Gazit D., (2003) Molecular imaging of the skeleton: Quantitative real time bioluminescence Monitoring gene expression in bone/skeletal repair and development. J Bone Miner Res 18: 570-578.

Wolf D., Lurain NS. Zuckerman T, Hoffman R. Saitinger J, Honigman A., Saleh N., Robert ES, Rowe JM., Kra-Oz Z., (2003) Emergence of late cytomegalovirus central nervous system disease in hematopoietic stem cell transplant recipients.Blood,101:463-465.

Zeira E., Manevitch A., Khatchatouriants A., Pappo O., Hyam E., Ben-Yehuda D., Tavor E., Honigman A., Lewis, A. and Galun E. (2003), Femtosecond infrared laser - an efficient and safe in vivo gene delivery system for prolonged expression. Mol Ther.,8:342-349.
54. Matza-Porges S, Tavor E, Panet A and A Honigman A (2003) Intracellular expression of a short peptide inhibits caspase3 activity and confers resistance to apoptosis. Exp.cell res., 290:60-67.

Aframian DJ, Amit D, Shai E, Baum BJ, Panet A, Honigman A, Deutsch D, Palmon A, (2003), Enhancement of functional firefly luciferase secretion from salivary epitheial cells. Journal of dental research 82: 379-379.

56. Abramovitz R., Tavor, E., Jacob-Hirch, J., Zeira, E., Amariglio, N., Pappo, O., Rechavi, G., Galun, E., and Honigman, A. (2004) A pivotal role of CREB in Tumor progression.. Cancer Res. 64: 1338-1346.

Borkow G., Lara H.H., Ayash-Rashkovsky M., Tavor E., Lapidot A., Bentwich Z., and Honigman A. (2004) Adenovirus bioluminescence reporter gene and cMAGI cell assay for the detection of HIV-1. Virus Genes 29: 257-265.

Panet A.; Braun;E., Honigman A.; and Steiner I., (2005) Involvement of Cellular Death Signals in the Reactivation of Herpes Simplex Virus Type 1 and Lambda Bacteriophage from a Latent State. Journal of Theoretical Biology 236: 88-94.

Arnon T., Achdout H., Levi O., MarkelG., Saleh N., Katz G., GazitR., Gross T., HannaJ., Nahari E., PorgadorA., Honigman A., Plachter B., Mevorach D., Wolf DG.and Mandelboim O., (2005). Interaction between the HCMV pp65 protein and the NK activating receptor NKp30 leads to general inhibition of NK cytotoxicity. Nat Immunol. 6: 515-523.

Matza-Porges S, Horresh I, Tavor E, Panet A.,and Honigman A., (2005). Expression of an Anti Apoptotic Recombinant Short Peptide in Mammalian Cells. Apoptosis, 10:987-996.
61. Azzeh M., Honigman A., Taraboulos A., Rouvinski A., and G. Wolf DG., (2006) Human Cytomegalovirus UL97 Kinase is involved in Remodeling of Viral Cytoplasmic Assembly Sites. Virology, 354:69-79.

Soreq H., Honigman A., (2007) It is all about resolution. FEBS J.; 274:924-927.

Aframian D.J, Amit D., David R., Shai E., Deutsch D., Honigman A, Panet A, and Palmon A., (2007) Re-Engineering Salivary Gland Cells to Enhance Protein Secretion For Use in Developing Artificial Salivary Gland Device. Tissue Engineering. 13: 995-1001.

Meyuhas R., Pikarsky E., Tavor E., Klar A., Abramovitch R., Hochman J., Honigman A., (2008)A key role for CREB in hypoxia mediated activation of the angiogenesis factor CYR61, in tumor cells Mol Cancer Res ;6:1397–11410.

Goldberg MD, Honigman A, Weinstein J, Chou S, Taraboulos A, Rouvinski A, Shinder V, Wolf DG. (2011) Human Cytomegalovirus UL97 Kinase and Non-Kinase Functions Mediate Viral Cytoplasmic Secondary Envelopment. J Virol. 2011 85: 3375-3384.

Lev, S., Honigman, A., Binshtok, A. M. (2014) Targeting charged cytotoxic compounds selectively into specific cells via TRP channels. Journal of molecular neuroscience, 53:104-105
68. Shneor D, Folberg R, Pe'er J, Honigman A, Frenkel S. (2017) Stable knockdown of CREB, HIF-1 and HIF-2 by replication competent retroviruses abrogates the responses to hypoxia in hepatocellular carcinoma. Cancer Gene Ther., 24:64-74.

Shneor D., Shay Tayeb S. , Pe’er J., Voropaev H., Gimmelshein M., Cassoux N., Honigman A and Frenkel S. (2018) A novel combinatorial treatment option for metastatic uveal melanoma. Oncotarget 9 :26096-26108

Voropaev H, Gimmelshein Vatkin M, Shneor D, Luski S, Honigman A, Frenkel S.(2019) Infectious Knockdown of CREB and HIF-1 for the Treatment of Metastatic Uveal Melanoma. Cancers 11(8). pii: E1056. doi: 10.3390/cancers11081056